Oxidative stress causes tissue lesions, affecting age pathologies. The restriction of proteins (PR) provides a powerful intervention strategy to reduce oxidative stress, which can haveRead More
Poly(ADP-ribose) polymerase inhibitors sensitize cancer cells to death receptor-mediated apoptosis by enhancing death receptor expression.
Apoptosis Ligand (Trail), Angonistic monoclonal antibodies to trail receptors and molecule trail receptor agonists are different from preclinical and pretty clinical trials as potential anti-cancerRead More
The Effects of Chain Length on the Structural Properties of Intrinsically Disordered Proteins in Concentrated Solutions
The disordered intrinsic proteins (IDP) are proteins that sample a heterogeneous set of solution in solution. It is estimated that 25 to 30% of allRead More
MicroRNA-451a prevents cutaneous squamous cell carcinoma progression via the 3-phosphoinositide-dependent protein kinase-1-mediated PI3K/AKT signaling pathway
The role of Micronas (MIRNAS / MIRS) in the government of the progression of cutaneous carcinoma (CSCC) was at the center of recent studies. However,Read More
The deryosination / retyrosing cycle is the most common post-translational modification of α-tubulin. Interestingly, for plants, the only qualified candidates of potential counterparts TTL areRead More
The thermal shock proteins (HSPS) are a large family of molecular chaperones expressed abanefully in cancer. The expression of HSPs in tumor cells has beenRead More
Genome-wide association study identifies common genetic variants associated with salivary gland carcinoma and its subtypes.
BACKGROUNDsalivary gland carcinoma (SGCs) is a rare malignancy with unknown etiology. The purpose of this research is to identify genetic variants modifying the risk ofRead More
cognitive impairment is a common and disabling problem in Parkinson’s disease (PD). Identification of genetic variants that influence the presence or severity of cognitive deficitsRead More
Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry.
association (GWA) studies have identified 19 independent genome loci general risk for endometriosis. Most variants of GWA is non-coding and the gene responsible for theRead More
Assessment of DNA repair susceptibility genes identified by whole exome sequencing in head and neck cancer.
We conduct exploratory biomarker study of a phase II clinical trial of eribulin plus gemcitabine (EG) versus paclitaxel plus gemcitabine (PG) in metastatic breast cancerRead More