Germline PARP4 mutations in patients with primary thyroid and breast cancers.

cognitive impairment is a common and disabling problem in Parkinson’s disease (PD). Identification of genetic variants that influence the presence or severity of cognitive deficits in PD may provide a clearer understanding of the underlying pathophysiology nonmotor this important feature. We genotypes 1105 PD patients of PD cognitive Genetics Consortium for variants using arrays NeuroX 249 336.

Participants assessment is doing the learning and memory (Hopkins Verbal Learning Test-Revised [HVLT-R]), working memory / executive function (Letter-Number Sequencing and Trail Making Test [TMT] A and B), language processing (semantic and phonemic verbal fluency ), visuospatial ability (Benton Judgment Line Orientation [Jolo]), and global cognitive function (Montreal cognitive Assessment).

For common variants, we used linear regression to test for association between genotype and cognitive performance with adjustment for important covariates. Rare variants were analyzed using a unified optimal kernel association test sequence. Threshold of significance was defined as a false discovery rate of corrected p-value (PFDR) 0.05. Eighteen common variants in 13 regions of the genome exceeds the threshold of significance for any of the cognitive tests.

This includes GBA rs2230288 (E326K; PFDR = 2.7 × 10-4) to Jolo, PARP4 rs9318600 (PFDR = 0.006), and rs9581094 (PFDR = 0.006) for HVLT-R total recall, and MTCL1 rs34877994 (PFDR = 0, 01) for TMT BA. Rare variant analysis did not produce significant gene region. We have conducted the first analysis of large-scale genetic PD cognitive and nominated some new suspected susceptibility genes for cognitive decline in PD. These results will require replication in an independent cohort of PD.

Germline PARP4 mutations in patients with primary thyroid and breast cancers.
Germline PARP4 mutations in patients with primary thyroid and breast cancers.

PARP4 germline mutations in patients with primary thyroid and breast cancer.

Germline mutations in the PTEN gene, which causes Cowden syndrome, which is known as one of the main genetic factor for thyroid and breast cancer; However, PTEN mutations are found in only a small proportion of study participants with non-syndrome, breast and thyroid cancer. In this study, we aimed to identify germline variants that may be associated with a major genetic risk of thyroid and breast cancer. Genomic DNA was extracted from peripheral blood of study participants WT PTEN 14 women with primary thyroid and breast cancer were analyzed by whole exome sequencing.

gene-based case-control association analysis using information from 406 Europeans were obtained from the 1000 Genome Project database identified 34 genes that might be associated with a phenotype with P <1.0 × 10 (-3). Among them, the rare variants in genes significantly PARP4 detected at high frequency (odds ratio = 5.2; P = 1.0 × 10 (-5)). Varian, G496V and T1170I, was found in six of the 14 study participants (43%) while only 0.5% of their frequency in the control.

functional analysis using the HCC1143 cell line showed that siRNA knockdown of PARP4 to significantly enhance cell proliferation compared to cells transfected with siControl (P = 0.02). Kaplan-Meier analysis using the Gene Expression Omnibus (GEO), the European Genome-phenome Archive (EGA) and The Cancer Genome Atlas (TCGA) dataset poor showing relapse-free survival (P <0.001, hazard ratio 1.27) and survival overall (P = 0.006, hazard ratio 1.41) in the low expression group PARP4, indicating that PARP4 may function as a tumor suppressor.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

DLR-PARP4-Hu-48T 48T
EUR 517
Description: A sandwich quantitative ELISA assay kit for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in samples from tissue homogenates or other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

DLR-PARP4-Hu-96T 96T
EUR 673
Description: A sandwich quantitative ELISA assay kit for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in samples from tissue homogenates or other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

RDR-PARP4-Hu-48Tests 48 Tests
EUR 544

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

RDR-PARP4-Hu-96Tests 96 Tests
EUR 756

PARP4 Antibody

1-CSB-PA007321
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PARP4. Recognizes PARP4 from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000

PARP4 Antibody

1-CSB-PA947926
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PARP4. Recognizes PARP4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

PARP4 Antibody

37796-100ul 100ul
EUR 252

PARP4 Antibody

DF2386 200ul
EUR 304
Description: PARP4 antibody detects endogenous levels of total PARP4.

PARP4 Antibody

ABD2386 100 ug
EUR 438

PARP4 antibody

10R-1680 100 ug
EUR 512
Description: Mouse monoclonal PARP4 antibody

PARP4 antibody

70R-33845 100 ug
EUR 327
Description: Rabbit polyclonal PARP4 antibody

Anti-PARP4 antibody

STJ119167 100 µl
EUR 277

Anti-PARP4 antibody

STJ110641 100 µl
EUR 277
Description: This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.

PARP4 Conjugated Antibody

C37796 100ul
EUR 397

PARP4 siRNA

20-abx927766
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

anti-PARP4

YF-PA23186 50 ul
EUR 334
Description: Mouse polyclonal to PARP4

PARP4 Rabbit pAb

A16749-100ul 100 ul
EUR 308

PARP4 Rabbit pAb

A16749-200ul 200 ul
EUR 459

PARP4 Rabbit pAb

A16749-20ul 20 ul
EUR 183

PARP4 Rabbit pAb

A16749-50ul 50 ul
EUR 223

PARP4 Rabbit pAb

A8343-100ul 100 ul
EUR 308

PARP4 Rabbit pAb

A8343-200ul 200 ul
EUR 459

PARP4 Rabbit pAb

A8343-20ul 20 ul
EUR 183

PARP4 Rabbit pAb

A8343-50ul 50 ul
EUR 223

PARP4 Blocking Peptide

DF2386-BP 1mg
EUR 195

Human PARP4 shRNA Plasmid

20-abx950100
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

PARP4 ELISA KIT|Human

EF007039 96 Tests
EUR 689

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx128291
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx119585
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx322903
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx339348
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx147654-100ug 100 ug
EUR 439

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx006130
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx174132
  • EUR 857.00
  • EUR 439.00
  • 1 mg
  • 200 ug

PARP4 ELISA Kit (Human) (OKDD00456)

OKDD00456 96 Wells
EUR 975
Description: Description of target: This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.;Species reactivity: Human;Application: ;Assay info: Quantitative Sandwich ELISA;Sensitivity: < 0.061 ng/mL

PARP4 ELISA Kit (Human) (OKCD08347)

OKCD08347 96 Wells
EUR 975
Description: Description of target: This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.061ng/mL

PARP4 ORF Vector (Human) (pORF)

ORF027423 1.0 ug DNA
EUR 405

Parp4 ORF Vector (Mouse) (pORF)

ORF053400 1.0 ug DNA
EUR 1572

PARP4 sgRNA CRISPR Lentivector set (Human)

K1595801 3 x 1.0 ug
EUR 339

Parp4 sgRNA CRISPR Lentivector set (Mouse)

K4858201 3 x 1.0 ug
EUR 339

PARP4-AS1 ORF Vector (Human) (pORF)

ORF027424 1.0 ug DNA Ask for price

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human)

4-PAC984Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4)

Recombinant Poly ADP Ribose Polymerase 4 (PARP4)

4-RPC984Hu01
  • EUR 458.40
  • EUR 226.00
  • EUR 1444.00
  • EUR 548.00
  • EUR 996.00
  • EUR 370.00
  • EUR 3460.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Poly ADP Ribose Polymerase 4 expressed in: E.coli

PARP4 sgRNA CRISPR Lentivector (Human) (Target 1)

K1595802 1.0 ug DNA
EUR 154

PARP4 sgRNA CRISPR Lentivector (Human) (Target 2)

K1595803 1.0 ug DNA
EUR 154

PARP4 sgRNA CRISPR Lentivector (Human) (Target 3)

K1595804 1.0 ug DNA
EUR 154

Parp4 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4858202 1.0 ug DNA
EUR 154

Parp4 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4858203 1.0 ug DNA
EUR 154

Parp4 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4858204 1.0 ug DNA
EUR 154

PARP4 3'UTR GFP Stable Cell Line

TU067410 1.0 ml
EUR 1394

PARP4 Protein Vector (Human) (pPB-C-His)

PV109690 500 ng Ask for price

PARP4 Protein Vector (Human) (pPB-N-His)

PV109691 500 ng Ask for price

PARP4 Protein Vector (Human) (pPM-C-HA)

PV109692 500 ng Ask for price

PARP4 Protein Vector (Human) (pPM-C-His)

PV109693 500 ng Ask for price

PARP4 Protein Vector (Mouse) (pPB-C-His)

PV213598 500 ng
EUR 3252

PARP4 Protein Vector (Mouse) (pPB-N-His)

PV213599 500 ng
EUR 3252

PARP4 Protein Vector (Mouse) (pPM-C-HA)

PV213600 500 ng
EUR 3252

PARP4 Protein Vector (Mouse) (pPM-C-His)

PV213601 500 ng
EUR 3252

PARP4 3'UTR Luciferase Stable Cell Line

TU017410 1.0 ml
EUR 1394

Parp4 3'UTR Luciferase Stable Cell Line

TU115923 1.0 ml Ask for price

Parp4 3'UTR GFP Stable Cell Line

TU165923 1.0 ml Ask for price

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), APC

4-PAC984Hu01-APC
  • EUR 345.00
  • EUR 3275.00
  • EUR 912.00
  • EUR 440.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with APC.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), Biotinylated

4-PAC984Hu01-Biotin
  • EUR 311.00
  • EUR 2460.00
  • EUR 727.00
  • EUR 381.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with Biotin.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), Cy3

4-PAC984Hu01-Cy3
  • EUR 419.00
  • EUR 4325.00
  • EUR 1175.00
  • EUR 545.00
  • EUR 251.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with Cy3.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), FITC

4-PAC984Hu01-FITC
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with FITC.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), HRP

4-PAC984Hu01-HRP
  • EUR 316.00
  • EUR 2855.00
  • EUR 807.00
  • EUR 398.00
  • EUR 206.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with HRP.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), PE

4-PAC984Hu01-PE
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with PE.

Human Poly ADP Ribose Polymerase 4 (PARP4) Protein

20-abx166526
  • EUR 648.00
  • EUR 272.00
  • EUR 1943.00
  • EUR 759.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), APC-Cy7

4-PAC984Hu01-APC-Cy7
  • EUR 571.00
  • EUR 6430.00
  • EUR 1705.00
  • EUR 760.00
  • EUR 319.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with APC-Cy7.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

SEC984Hu-10x96wellstestplate 10x96-wells test plate
EUR 4731.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in Tissue homogenates and other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

SEC984Hu-1x48wellstestplate 1x48-wells test plate
EUR 477.3
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in Tissue homogenates and other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

SEC984Hu-1x96wellstestplate 1x96-wells test plate
EUR 639
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in Tissue homogenates and other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

SEC984Hu-5x96wellstestplate 5x96-wells test plate
EUR 2575.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in Tissue homogenates and other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

4-SEC984Hu
  • EUR 4782.00
  • EUR 2526.00
  • EUR 640.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Poly ADP Ribose Polymerase 4 (PARP4) CLIA Kit

20-abx494031
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Pig Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx360853-96tests 96 tests
EUR 825

Rabbit Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx363456-96tests 96 tests
EUR 825

Chicken Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx355780-96tests 96 tests
EUR 825

Monkey Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx358874-96tests 96 tests
EUR 825

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

20-abx152651
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Poly ADP Ribose Polymerase 4 (PARP4) CLIA Kit

abx197521-96tests 96 tests
EUR 825

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx252901-96tests 96 tests
EUR 707

Human PARP4(Poly ADP Ribose Polymerase 4) ELISA Kit

EH3510 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human Poly [ADP- ribose] polymerase 4, PARP4 ELISA KIT

ELI-12310h 96 Tests
EUR 824

PARP4-AS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV739631 1.0 ug DNA Ask for price

PARP4-AS1 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV739635 1.0 ug DNA Ask for price

PARP4-AS1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV739636 1.0 ug DNA Ask for price

ELISA kit for Human PARP4 (Poly ADP Ribose Polymerase 4)

E-EL-H2420 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Human PARP4 (Poly ADP Ribose Polymerase 4) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Human PARP4 (Poly ADP Ribose Polymerase 4)

E-CL-H1422 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Human PARP4 (Poly ADP Ribose Polymerase 4) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human PARP4 (Poly ADP Ribose Polymerase 4)

ELK3564 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Poly ADP Ribose Polymerase 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

PARP4 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K1595805 3 x 1.0 ug
EUR 376

Parp4 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K4858205 3 x 1.0 ug
EUR 376

PARP4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K1595806 1.0 ug DNA
EUR 167

PARP4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K1595807 1.0 ug DNA
EUR 167

PARP4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K1595808 1.0 ug DNA
EUR 167

Parp4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)

K4858206 1.0 ug DNA
EUR 167

Parp4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

K4858207 1.0 ug DNA
EUR 167

Parp4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)

K4858208 1.0 ug DNA
EUR 167

PARP4-AS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV739632 1.0 ug DNA Ask for price

PARP4-AS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV739633 1.0 ug DNA Ask for price

PARP4-AS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV739634 1.0 ug DNA Ask for price

CD11b Antibody Antibody

ABD2911 100 ug
EUR 438

H2B Antibody Antibody

AF4659 200ul
EUR 376
Description: H2B Antibody Antibody detects endogenous levels of H2B.

anti- Antibody^Polyclonal antibody control antibody

LSMab09882 100 ug
EUR 438

Antibody

A1360-500 Ask for price

Anti-Anti-SEPT2 Antibody antibody

STJ25475 100 µl
EUR 277

Anti-Anti-SEPT5 Antibody antibody

STJ25477 100 µl
EUR 277
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.

Anti-Anti-SEPT8 Antibody antibody

STJ25479 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-Anti-SEPT2 Antibody antibody

STJ28365 100 µl
EUR 277

Anti-Anti-SEPT7 Antibody antibody

STJ28963 100 µl
EUR 277
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.

Anti-Anti-SEPT8 Antibody antibody

STJ117206 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-Anti-SEPT12 Antibody antibody

STJ117759 100 µl
EUR 277
Description: This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene.

Anti-Anti-MARCH6 Antibody antibody

STJ118549 100 µl
EUR 277

Anti-Anti-MARCH6 Antibody antibody

STJ118550 100 µl
EUR 277

Anti-Anti-MARCH7 Antibody antibody

STJ118752 100 µl
EUR 277

Anti-Anti-SEPT3 Antibody antibody

STJ118990 100 µl
EUR 277

Anti-Anti-SEPT1 antibody antibody

STJ119580 100 µl
EUR 277
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]

Anti-Anti-SEPT7 Antibody antibody

STJ116214 100 µl
EUR 277
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.

Anti-Anti-SEPT6 antibody antibody

STJ11100949 100 µl
EUR 277
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.

Anti-Anti-SEPT9 Antibody antibody

STJ111369 100 µl
EUR 277
Description: This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.

Anti-Anti-SEPT11 Antibody antibody

STJ111530 100 µl
EUR 277

Anti-Anti-SEPT4 Antibody antibody

STJ112276 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer.

Anti-Anti-MARCH9 Antibody antibody

STJ112609 100 µl
EUR 277

Anti-Anti-SEPT11 Antibody antibody

STJ113941 100 µl
EUR 277

Anti-Anti-SEPT11 Antibody antibody

STJ114081 100 µl
EUR 277

Anti-Anti-SEPT5 Antibody antibody

STJ114819 100 µl
EUR 277
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.

Anti-Anti-MARCH8 Antibody antibody

STJ114828 100 µl
EUR 277

Ly1 Antibody Reactive (LYAR) Antibody

20-abx123734
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul

Anti-Glycoprotein Antibody (GP) Antibody

20-abx319900
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Anti-Glycoprotein Antibody (GP) Antibody

20-abx319901
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Anti-Glycoprotein Antibody (GP) Antibody

20-abx319905
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Anti-Glycoprotein Antibody (GP) Antibody

20-abx319913
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Ly1 Antibody Reactive (LYAR) Antibody

20-abx311665
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Anti-Glycolipid Antibody (AGA) Antibody

20-abx004855
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Anti-Glycolipid Antibody (AGA) Antibody

abx036399-100ug 100 ug
EUR 391

Ly1 Antibody Reactive (LYAR) Antibody

20-abx008109
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Ly1 Antibody Reactive (LYAR) Antibody

20-abx014333
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Ly1 Antibody Reactive (LYAR) Antibody

abx033330-400ul 400 ul
EUR 523

Ly1 Antibody Reactive (LYAR) Antibody

abx033330-80l 80 µl
EUR 286

Ly1 Antibody Reactive (LYAR) Antibody

abx234901-100ug 100 ug
EUR 551

Anti-Glycolipid Antibody (AGA) Antibody

abx230204-100ug 100 ug
EUR 481

Ly1 Antibody Reactive (LYAR) Antibody

20-abx324434
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Monoclonal NGF/proNGF Neutralizing Antibody Antibody

AMM06679G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human NGF/proNGF Neutralizing. The antibodies are raised in Mouse. This antibody is applicable in E

Anti CD22 Antibody: CD22 Monoclonal Antibody

065-A-01mg 0,1 mg
EUR 267.5
Description: anti-CD22 monoclonal antibody

Anti CD22 Antibody: CD22 Monoclonal Antibody

065-A-1000ug 1000 ug
EUR 1282.5
Description: anti-CD22 monoclonal antibody

Anti-IgG1 Negative Control Antibody antibody

STJ16100881 1 mL
EUR 478

Anti-Noelin Antibody BIOTIN Antibody BIOTIN

STJ501938 100 µg
EUR 586

Anti-Noelin Antibody FITC Antibody FITC

STJ501939 100 µg
EUR 586

Anti-Noelin Antibody BIOTIN Antibody BIOTIN

STJ501940 100 µg
EUR 586

Anti-Noelin Antibody FITC Antibody FITC

STJ501941 100 µg
EUR 586

Antibody for Human alpha Tubulin Antibody

SPC-692D 0.1mg
EUR 354
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is unconjugated.

Antibody for Human alpha Tubulin Antibody

SPC-692D-A390 0.1mg
EUR 401
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 390.

Antibody for Human alpha Tubulin Antibody

SPC-692D-A488 0.1mg
EUR 400
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 488.

Antibody for Human alpha Tubulin Antibody

SPC-692D-A565 0.1mg
EUR 400
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 565.

Antibody for Human alpha Tubulin Antibody

SPC-692D-A594 0.1mg
EUR 400
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 594.

Antibody for Human alpha Tubulin Antibody

SPC-692D-A633 0.1mg
EUR 400
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 633.

Antibody for Human alpha Tubulin Antibody

SPC-692D-A655 0.1mg
EUR 400
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 655.

Antibody for Human alpha Tubulin Antibody

SPC-692D-A680 0.1mg
EUR 400
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 680.

Antibody for Human alpha Tubulin Antibody

SPC-692D-A700 0.1mg
EUR 400
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 700.

In conclusion, we identified susceptibility genes possibility PARP4 as the primary thyroid and breast cancer.