Germline PARP4 mutations in patients with primary thyroid and breast cancers.

cognitive impairment is a common and disabling problem in Parkinson’s disease (PD). Identification of genetic variants that influence the presence or severity of cognitive deficits in PD may provide a clearer understanding of the underlying pathophysiology nonmotor this important feature. We genotypes 1105 PD patients of PD cognitive Genetics Consortium for variants using arrays NeuroX 249 336.

Participants assessment is doing the learning and memory (Hopkins Verbal Learning Test-Revised [HVLT-R]), working memory / executive function (Letter-Number Sequencing and Trail Making Test [TMT] A and B), language processing (semantic and phonemic verbal fluency ), visuospatial ability (Benton Judgment Line Orientation [Jolo]), and global cognitive function (Montreal cognitive Assessment).

For common variants, we used linear regression to test for association between genotype and cognitive performance with adjustment for important covariates. Rare variants were analyzed using a unified optimal kernel association test sequence. Threshold of significance was defined as a false discovery rate of corrected p-value (PFDR) 0.05. Eighteen common variants in 13 regions of the genome exceeds the threshold of significance for any of the cognitive tests.

This includes GBA rs2230288 (E326K; PFDR = 2.7 × 10-4) to Jolo, PARP4 rs9318600 (PFDR = 0.006), and rs9581094 (PFDR = 0.006) for HVLT-R total recall, and MTCL1 rs34877994 (PFDR = 0, 01) for TMT BA. Rare variant analysis did not produce significant gene region. We have conducted the first analysis of large-scale genetic PD cognitive and nominated some new suspected susceptibility genes for cognitive decline in PD. These results will require replication in an independent cohort of PD.

Germline PARP4 mutations in patients with primary thyroid and breast cancers.
Germline PARP4 mutations in patients with primary thyroid and breast cancers.

PARP4 germline mutations in patients with primary thyroid and breast cancer.

Germline mutations in the PTEN gene, which causes Cowden syndrome, which is known as one of the main genetic factor for thyroid and breast cancer; However, PTEN mutations are found in only a small proportion of study participants with non-syndrome, breast and thyroid cancer. In this study, we aimed to identify germline variants that may be associated with a major genetic risk of thyroid and breast cancer. Genomic DNA was extracted from peripheral blood of study participants WT PTEN 14 women with primary thyroid and breast cancer were analyzed by whole exome sequencing.

gene-based case-control association analysis using information from 406 Europeans were obtained from the 1000 Genome Project database identified 34 genes that might be associated with a phenotype with P <1.0 × 10 (-3). Among them, the rare variants in genes significantly PARP4 detected at high frequency (odds ratio = 5.2; P = 1.0 × 10 (-5)). Varian, G496V and T1170I, was found in six of the 14 study participants (43%) while only 0.5% of their frequency in the control.

functional analysis using the HCC1143 cell line showed that siRNA knockdown of PARP4 to significantly enhance cell proliferation compared to cells transfected with siControl (P = 0.02). Kaplan-Meier analysis using the Gene Expression Omnibus (GEO), the European Genome-phenome Archive (EGA) and The Cancer Genome Atlas (TCGA) dataset poor showing relapse-free survival (P <0.001, hazard ratio 1.27) and survival overall (P = 0.006, hazard ratio 1.41) in the low expression group PARP4, indicating that PARP4 may function as a tumor suppressor.

PARP4 Antibody
37796 100ul
EUR 319

PARP4 Antibody
37796-100ul 100ul
EUR 302.4

PARP4 Antibody
1-CSB-PA947926
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Description: A polyclonal antibody against PARP4. Recognizes PARP4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

PARP4 Antibody
E037796 100μg/100μl
EUR 255
Description: Available in various conjugation types.

PARP4 Antibody
E11-13099C 100μg
EUR 225
Description: Available in various conjugation types.

PARP4 Antibody
DF2386 200ul
EUR 420

PARP4 Antibody
DF2386-100ul 100ul
EUR 280

PARP4 Antibody
DF2386-200ul 200ul
EUR 350

PARP4 Antibody
E98343 100ul
EUR 255
Description: Available in various conjugation types.

PARP4 antibody
70R-33845 100 ug
EUR 294
Description: Rabbit polyclonal PARP4 antibody

PARP4 Antibody
1-CSB-PA007321
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  • 100ug
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Description: A polyclonal antibody against PARP4. Recognizes PARP4 from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000

PARP4 Antibody
ABD2386 100ug
EUR 325

PARP4 Antibody
MBS7129453-005mL 0.05mL
EUR 190

PARP4 Antibody
MBS7129453-01mL 0.1mL
EUR 270

PARP4 Antibody
MBS7129453-5x01mL 5x0.1mL
EUR 1205

PARP4 Antibody
MBS7119050-005mg 0.05mg
EUR 150

PARP4 Antibody
MBS7119050-01mg 0.1mg
EUR 190

PARP4 Antibody
MBS7119050-5x01mg 5x0.1mg
EUR 845

PARP4 Antibody
MBS9404373-01mL 0.1mL
EUR 305

PARP4 Antibody
MBS9404373-5x01mL 5x0.1mL
EUR 1230

PARP4 Antibody
MBS854153-01mg 0.1mg
EUR 305

PARP4 Antibody
MBS854153-01mLAF405L 0.1mL(AF405L)
EUR 465

PARP4 Antibody
MBS854153-01mLAF405S 0.1mL(AF405S)
EUR 465

PARP4 Antibody
MBS854153-01mLAF610 0.1mL(AF610)
EUR 465

PARP4 Antibody
MBS854153-01mLAF635 0.1mL(AF635)
EUR 465

PARP4 Antibody
MBS9603901-01mL 0.1mL
EUR 260

PARP4 Antibody
MBS9603901-02mL 0.2mL
EUR 305

PARP4 Antibody
MBS9603901-5x02mL 5x0.2mL
EUR 1220

PARP4 Antibody
MBS9505846-005mL 0.05mL
EUR 285

PARP4 Antibody
MBS9505846-01mL 0.1mL
EUR 385

PARP4 Antibody
MBS9505846-5x01mL 5x0.1mL
EUR 1590

PARP4 Polyclonal Antibody
E916749 100ul
EUR 225
Description: Available in various conjugation types.

PARP4 Conjugated Antibody
C37796 100ul
EUR 476.4

PARP4 Polyclonal Antibody
E-AB-91627-120uL 120uL
EUR 320
Description: Unconjugated

PARP4 Polyclonal Antibody
E-AB-91627-200uL 200uL
EUR 530
Description: Unconjugated

PARP4 Polyclonal Antibody
E-AB-91627-60uL 60uL
EUR 200
Description: Unconjugated

PARP4 Polyclonal Antibody
E-AB-91627-each each Ask for price
Description: Unconjugated

PARP4 Polyclonal Antibody
MBS9238172-01mL 0.1mL
EUR 415

PARP4 Polyclonal Antibody
MBS9238172-5x01mL 5x0.1mL
EUR 1841

PARP4 Polyclonal Antibody
MBS8571391-01mL 0.1mL
EUR 305

PARP4 Polyclonal Antibody
MBS8571391-01mLAF405L 0.1mL(AF405L)
EUR 565

PARP4 Polyclonal Antibody
MBS8571391-01mLAF405S 0.1mL(AF405S)
EUR 565

PARP4 Polyclonal Antibody
MBS8571391-01mLAF610 0.1mL(AF610)
EUR 565

PARP4 Polyclonal Antibody
MBS8571391-01mLAF635 0.1mL(AF635)
EUR 565

PARP4 Polyclonal Antibody
MBS9128629-002mL 0.02mL
EUR 200

PARP4 Polyclonal Antibody
MBS9128629-005mL 0.05mL
EUR 255

PARP4 Polyclonal Antibody
MBS9128629-01mL 0.1mL
EUR 345

PARP4 Polyclonal Antibody
MBS9128629-02mL 0.2mL
EUR 545

PARP4 Polyclonal Antibody
MBS9128629-5x02mL 5x0.2mL
EUR 2265

PARP4 Polyclonal Antibody
MBS2521137-002mL 0.02mL
EUR 140

PARP4 Polyclonal Antibody
MBS2521137-006mL 0.06mL
EUR 180

PARP4 Polyclonal Antibody
MBS2521137-012mL 0.12mL
EUR 260

PARP4 Polyclonal Antibody
MBS2521137-02mL 0.2mL
EUR 405

PARP4 Polyclonal Antibody
MBS2540604-006mL 0.06mL
EUR 180

PARP4 Polyclonal Antibody
MBS2540604-012mL 0.12mL
EUR 260

PARP4 Polyclonal Antibody
MBS2540604-02mL 0.2mL
EUR 405

PARP4 Polyclonal Antibody
MBS2540604-5x02mL 5x0.2mL
EUR 1725

PARP4 Conjugated Antibody
MBS9448234-01mLAF350 0.1mL(AF350)
EUR 480

PARP4 Conjugated Antibody
MBS9448234-01mLAF405 0.1mL(AF405)
EUR 480

PARP4 Conjugated Antibody
MBS9448234-01mLAF488 0.1mL(AF488)
EUR 480

PARP4 Conjugated Antibody
MBS9448234-01mLAF555 0.1mL(AF555)
EUR 480

PARP4 Conjugated Antibody
MBS9448234-01mLBiotin 0.1mL(Biotin)
EUR 480

OACD06303-1ML - PARP4 Antibody
OACD06303-1ML 1ml
EUR 669

OAAN02690-50UL - PARP4 Antibody
OAAN02690-50UL 50ul
EUR 149

OACD06303-100UL - PARP4 Antibody
OACD06303-100UL 100ul
EUR 199

OAAF03061-100UG - PARP4 Antibody
OAAF03061-100UG 100ug
EUR 329

OAAN02690-100UL - PARP4 Antibody
OAAN02690-100UL 100ul
EUR 249

OAAN02690-200UL - PARP4 Antibody
OAAN02690-200UL 200ul
EUR 389

PARP4 Rabbit Polyclonal Antibody
54277 100ul
EUR 439

PARP4 Rabbit Polyclonal Antibody
E10G12021 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PARP4 Rabbit Polyclonal Antibody
MBS9465482-005mL 0.05mL
EUR 300

PARP4 Rabbit Polyclonal Antibody
MBS9465482-01mL 0.1mL
EUR 390

PARP4 Rabbit Polyclonal Antibody
MBS9465482-5x01mL 5x0.1mL
EUR 1610

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
20-abx119585
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  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
20-abx128291
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
abx147654-100ug 100 ug
EUR 526.8

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
20-abx006130
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  • 100 ul
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  • 20 ul
  • 50 ul

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
20-abx174132
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  • 1 mg
  • 200 ug

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
20-abx322903
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  • 100 ug
  • 50 ug

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
20-abx339348
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  • 100 ul
  • 50 ul

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
abx128291-100l 100 µl
EUR 275

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
abx128291-1ml 1 ml
EUR 750

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
abx128291-200l 200 µl
EUR 337.5

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
abx174132-100l 100 µl
EUR 787.5

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
abx174132-1ml 1 ml Ask for price

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
abx174132-200l 200 µl Ask for price

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
abx119585-100l 100 µl
EUR 312.5

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
abx119585-20l 20 µl
EUR 43.75

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
abx119585-50l 50 µl
EUR 237.5

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
abx339348-100l 100 µl
EUR 350

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
abx339348-50l 50 µl
EUR 250

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
abx322903-100g 100 µg
EUR 250

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
abx322903-50g 50 µg
EUR 187.5

Poly ADP Ribose Polymerase 4 (PARP4) Antibody
abx006130-100l 100 µl
EUR 175

PARP4
MBS8536702-01mL 0.1mL
EUR 325

PARP4
MBS8536702-01mLAF405L 0.1mL(AF405L)
EUR 565

PARP4
MBS8536702-01mLAF405S 0.1mL(AF405S)
EUR 565

PARP4
MBS8536702-01mLAF610 0.1mL(AF610)
EUR 565

PARP4
MBS8536702-01mLAF635 0.1mL(AF635)
EUR 565

PARP4/VPARP Rabbit anti-Human Polyclonal Antibody
MBS2402951-005mL 0.05mL
EUR 615

PARP4/VPARP Rabbit anti-Human Polyclonal Antibody
MBS2402951-5x005mL 5x0.05mL
EUR 2605

PARP4 mouse monoclonal antibody, clone P193-6, Liquid
AM32037SU-N 1 ml Ask for price

PARP4 mouse monoclonal antibody, clone P193-4, Liquid
AM32038SU-N 1 ml Ask for price

PARP4 mouse monoclonal antibody, clone P193-10, Liquid
AM32039SU-N 1 ml Ask for price

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody
CAU23692-100ul 100ul
EUR 235.2

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody
CAU23692-200ul 200ul
EUR 294

PARP4 siRNA
20-abx927766
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  • 15 nmol
  • 30 nmol

Polyclonal Antibody to Poly ADP Ribose Polymerase 4 (PARP4)
PAC984Hu01 100ul
EUR 245

Polyclonal Antibody to Poly ADP Ribose Polymerase 4 (PARP4)
MBS2026636-01mL 0.1mL
EUR 175

Polyclonal Antibody to Poly ADP Ribose Polymerase 4 (PARP4)
MBS2026636-02mL 0.2mL
EUR 220

Polyclonal Antibody to Poly ADP Ribose Polymerase 4 (PARP4)
MBS2026636-05mL 0.5mL
EUR 355

Polyclonal Antibody to Poly ADP Ribose Polymerase 4 (PARP4)
MBS2026636-1mL 1mL
EUR 435

Polyclonal Antibody to Poly ADP Ribose Polymerase 4 (PARP4)
MBS2026636-5mL 5mL
EUR 1185

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human)
4-PAC984Hu01
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  • 100ul
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  • 1ml
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Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4)

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), PE
4-PAC984Hu01-PE
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  • 100ul
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  • 200ul
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Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with PE.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), APC
4-PAC984Hu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with APC.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), Cy3
4-PAC984Hu01-Cy3
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  • 100ul
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  • 200ul
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Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with Cy3.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), HRP
4-PAC984Hu01-HRP
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  • 100ul
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Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with HRP.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), FITC
4-PAC984Hu01-FITC
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  • 100ul
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  • 200ul
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Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with FITC.

PARP4 Rabbit pAb
A8343-200ul 200 ul
EUR 550.8

PARP4 Rabbit pAb
A8343-20ul 20 ul
EUR 219.6

PARP4 Rabbit pAb
E2508343 100ul
EUR 225
Description: Available in various conjugation types.

PARP4 Rabbit pAb
A16749-100ul 100 ul
EUR 369.6

PARP4 Rabbit pAb
A16749-200ul 200 ul
EUR 550.8

PARP4 Rabbit pAb
A16749-20ul 20 ul
EUR 219.6

PARP4 Rabbit pAb
A16749-50ul 50 ul
EUR 267.6

PARP4 Rabbit pAb
MBS9142439-002mL 0.02mL
EUR 200

PARP4 Rabbit pAb
MBS9142439-005mL 0.05mL
EUR 255

PARP4 Rabbit pAb
MBS9142439-01mL 0.1mL
EUR 345

PARP4 Rabbit pAb
MBS9142439-02mL 0.2mL
EUR 545

PARP4 Rabbit pAb
MBS9142439-5x02mL 5x0.2mL
EUR 2265

PARP4 Rabbit pAb
MBS8547363-01mL 0.1mL
EUR 305

PARP4 Rabbit pAb
MBS8547363-01mLAF405L 0.1mL(AF405L)
EUR 565

PARP4 Rabbit pAb
MBS8547363-01mLAF405S 0.1mL(AF405S)
EUR 565

PARP4 Rabbit pAb
MBS8547363-01mLAF610 0.1mL(AF610)
EUR 565

PARP4 Rabbit pAb
MBS8547363-01mLAF635 0.1mL(AF635)
EUR 565

PARP4 Rabbit pAb
A16749 500μL
EUR 173.58

PARP4 Rabbit pAb
A8343 500μL
EUR 1246.96

PARP4 siRNA (Human)
MBS8218597-15nmol 15nmol
EUR 405

PARP4 siRNA (Human)
MBS8218597-30nmol 30nmol
EUR 565

PARP4 siRNA (Human)
MBS8218597-5x30nmol 5x30nmol
EUR 2450

Human Poly ADP Ribose Polymerase 4 (PARP4) Antibody Pair Kit (with Standard)
MBS2102206-10x96Tests 10x96Tests
EUR 1480

Human Poly ADP Ribose Polymerase 4 (PARP4) Antibody Pair Kit (with Standard)
MBS2102206-10x96TestsMBS2090685AbPairsSupportPack110x96Tests 10x96Tests+MBS2090685(AbPairsSupportPack1,10x96Tests)
EUR 1600

Human Poly ADP Ribose Polymerase 4 (PARP4) Antibody Pair Kit (with Standard)
MBS2102206-5x96Tests 5x96Tests
EUR 935

Human Poly ADP Ribose Polymerase 4 (PARP4) Antibody Pair Kit (with Standard)
MBS2102206-5x96TestsMBS2090685AbPairsSupportPack15x96Tests 5x96Tests+MBS2090685(AbPairsSupportPack1,5x96Tests)
EUR 1010

PARP4 Blocking Peptide
DF2386-BP 1mg
EUR 234

PARP4 Blocking Peptide
MBS9622619-1mg 1mg
EUR 380

PARP4 Blocking Peptide
MBS9622619-5x1mg 5x1mg
EUR 1650

Recombinant Human PARP4
MBS7611640-005mg 0.05mg
EUR 405

Recombinant Human PARP4
MBS7611640-02mg 0.2mg
EUR 760

Recombinant Human PARP4
MBS7611640-1mg 1mg
EUR 2175

Recombinant Human PARP4
MBS7611640-5x1mg 5x1mg
EUR 8410

Recombinant Human Protein mono-ADP-ribosyltransferase PARP4 (PARP4), partial
CSB-EP892136HU 8890 mg Ask for price

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), Biotinylated
4-PAC984Hu01-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with Biotin.

PE-Linked Polyclonal Antibody to Poly ADP Ribose Polymerase 4 (PARP4)
MBS2069301-01mL 0.1mL
EUR 265

PE-Linked Polyclonal Antibody to Poly ADP Ribose Polymerase 4 (PARP4)
MBS2069301-02mL 0.2mL
EUR 355

PE-Linked Polyclonal Antibody to Poly ADP Ribose Polymerase 4 (PARP4)
MBS2069301-05mL 0.5mL
EUR 660

PE-Linked Polyclonal Antibody to Poly ADP Ribose Polymerase 4 (PARP4)
MBS2069301-1mL 1mL
EUR 810

PE-Linked Polyclonal Antibody to Poly ADP Ribose Polymerase 4 (PARP4)
MBS2069301-5mL 5mL
EUR 2330

In conclusion, we identified susceptibility genes possibility PARP4 as the primary thyroid and breast cancer.