Genome-wide association study identifies common genetic variants associated with salivary gland carcinoma and its subtypes.

BACKGROUND
salivary gland carcinoma (SGCs) is a rare malignancy with unknown etiology. The purpose of this research is to identify genetic variants modifying the risk of SGC and major subtypes: adenoid cystic carcinoma and mucoepidermoid carcinoma.


METHOD
The author conducted a genome-wide association study in 309 cases defined SGC and 535 cancer-free controls. A single-nucleotide polymorphism (SNP) discovery -level studies conducted in non-Hispanic white individuals was followed by a replication study on Hispanic individuals. A logistic regression analysis was applied to calculate the odds ratio (OR) and 95% confidence intervals (95% CI). A meta-analysis of the results is done.


RESULTS
A genome-wide significant association with SGC in non-Hispanic white individuals detected in the coding SNP in CHRNA2 (cholinergic receptor, nicotinic, alpha 2 [neuronal]) (OR, 8.55; 95% CI, 4.53 to 16.13 [ P = 3.6 × 10 (-11)]), OR4F15 (olfactory receptor, family 4, subfamily M, member 15) (OR, 5.26; 95% CI, 3.13 to 8.83 [P = 3 , 5 × 10 (-10)]), ZNF343 (zinc finger protein 343) (OR, 3.28; 95% CI, 2.12 to 5.07 [P = 9.1 × 10 (-8)]), and PARP4 (poly (ADP-ribose) polymerase family, member 4) (OR, 2:00; 95% CI, 1.54 to 2.59 [P = 1.7 × 10 (-7)]).

Meta-analysis of a cohort of non-Hispanic white and Hispanic identified another significant genome-wide SNP in ELL2 (meta-OR, 1.86; 95% CI, 1.48 to 2.34 [P = 1.3 × 10 (-7 )]). most of the risk allele enriched in mucoepidermoid carcinoma, in which the SNP in CHRNA2, OR4F15, and ZNF343 had an OR of 15.71 (95% CI, 6.59 to 37.47 [P = 5.2 × 10 (-10)]), 15.60 (95% CI, 6.50 to 37.41 [P = 7.5 × 10 (-10)]), and 6.49 (95% CI, 3.36 to 12.52 [P = 2.5 × 10 (-8)]), respectively. None of these SNPs maintained a significant relationship with adenoid cystic carcinoma.


CONCLUSION
To the best of the authors’ knowledge, this is the first study to identify SNPs associated with the risk panel SGC. Confirmation of these findings along with the functional analysis of SNPs identified necessary.

Genome-wide association study identifies common genetic variants associated with salivary gland carcinoma and its subtypes.
Genome-wide association study identifies common genetic variants associated with salivary gland carcinoma and its subtypes.

Prospective new biomarkers for Metastatic Colorectal Cancer: A Meta-analysis In Vitro Studies.

Colorectal cancer (CRC) is one of the most common cancers and deadly. Although many studies have evaluated the potential biomarkers for early diagnosis, biomarkers date have failed to reach an acceptable level of accuracy for distant metastases. In this paper, we performed a meta-analysis of gene sets of microarray studies in vitro and combine the results from this study with previously published data to validate the proteomics and advise potential prognostic for CRC metastases.

Two microarray data sets including 21 genes significant finding. Of these significant genes, ALDOA, IL8 (CXCL8), and PARP4 has strong potential as a potential prognostic. LAMB2, MCM7, CXCL23A, SERPINA3, ABCA3, ALDH3A2, and POLR2I also has potential. Other candidates are more controversial, perhaps because of the biological heterogeneity of tumor cells, which is a major obstacle to predict metastasis. In conclusion, we show meta-analysis approach and successfully advise potential biomarker ten for future investigations.


hepatocellular carcinoma (HCC), the most common type of liver cancer, is the third leading cause of cancer deaths worldwide related. The molecular mechanisms underlying the initiation and formation of HCC remains unclear. In this study, we performed exome sequencing using a tumor and normal tissue of 3 hepatitis B virus (HBV) -positive BCLC stage

PARP4 antibody

10R-1680 100 ug
EUR 614.4
Description: Mouse monoclonal PARP4 antibody

PARP4 Antibody

37796 100ul
EUR 319

PARP4 Antibody

37796-100ul 100ul
EUR 302.4

PARP4 Antibody

1-CSB-PA947926
  • Ask for price
  • Ask for price
  • 50ul
  • 100ul
Description: A polyclonal antibody against PARP4. Recognizes PARP4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

PARP4 Antibody

1-CSB-PA007321
  • Ask for price
  • Ask for price
  • 50ug
  • 100ug
Description: A polyclonal antibody against PARP4. Recognizes PARP4 from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000

PARP4 Antibody

E037796 100μg/100μl
EUR 255
Description: Available in various conjugation types.

PARP4 Antibody

DF2386 200ul
EUR 420

PARP4 Antibody

DF2386-100ul 100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)

PARP4 Antibody

DF2386-200ul 200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)

PARP4 Antibody

E11-13099C 100μg
EUR 225
Description: Available in various conjugation types.

PARP4 Antibody

E98343 100ul
EUR 255
Description: Available in various conjugation types.

PARP4 Antibody

MBS854153-01mg 0.1mg
EUR 305

PARP4 Antibody

MBS854153-01mLAF405L 0.1mL(AF405L)
EUR 465

PARP4 Antibody

MBS854153-01mLAF405S 0.1mL(AF405S)
EUR 465

PARP4 Antibody

MBS854153-01mLAF610 0.1mL(AF610)
EUR 465

PARP4 Antibody

MBS854153-01mLAF635 0.1mL(AF635)
EUR 465

PARP4 Antibody

MBS7129453-005mL 0.05mL
EUR 190

PARP4 Antibody

MBS7129453-01mL 0.1mL
EUR 270

PARP4 Antibody

MBS7129453-5x01mL 5x0.1mL
EUR 1205

PARP4 Antibody

MBS7119050-005mg 0.05mg
EUR 150

PARP4 Antibody

MBS7119050-01mg 0.1mg
EUR 190

PARP4 Antibody

MBS7119050-5x01mg 5x0.1mg
EUR 845

PARP4 Antibody

MBS9404373-01mL 0.1mL
EUR 305

PARP4 Antibody

MBS9404373-5x01mL 5x0.1mL
EUR 1230

PARP4 Antibody

MBS9603901-01mL 0.1mL
EUR 260

PARP4 Antibody

MBS9603901-02mL 0.2mL
EUR 305

PARP4 Antibody

MBS9603901-5x02mL 5x0.2mL
EUR 1220

PARP4 Antibody

MBS9505846-005mL 0.05mL
EUR 285

PARP4 Antibody

MBS9505846-01mL 0.1mL
EUR 385

PARP4 Antibody

MBS9505846-5x01mL 5x0.1mL
EUR 1590

Primary antibody

F40001-0.08ML 0.08 ml
EUR 157.25
Description: Monoclonal (mouse origin)

Primary antibody

F40001-0.4ML 0.4 ml
EUR 339.15
Description: Monoclonal (mouse origin)

Primary antibody

F40002-0.08ML 0.08 ml
EUR 157.25
Description: Monoclonal (mouse origin)

Primary antibody

F40002-0.4ML 0.4 ml
EUR 339.15
Description: Monoclonal (mouse origin)

Primary antibody

F40003-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40003-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40004-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40004-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40005-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40005-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40007-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40007-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40008-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40008-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40009-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40009-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40010-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40010-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40011-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40011-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40012-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40012-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40013-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40013-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40014-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40014-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40015-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40015-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40016-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40016-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40017-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40017-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40018-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40018-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40019-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40019-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40020-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40020-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40021-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40021-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40022-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40022-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40023-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40023-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40024-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40024-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40025-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40025-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40026-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40026-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40027-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40027-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40028-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40028-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40029-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40029-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40030-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40030-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40031-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40031-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40032-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40032-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40033-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40033-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40034-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40034-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40035-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40035-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40036-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40036-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40037-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40037-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40038-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40038-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40039-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40039-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40040-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40040-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40041-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40041-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40042-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40042-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40043-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40043-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40044-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40044-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40045-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40045-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40046-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40046-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40047-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40047-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40048-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40048-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40050-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40050-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40051-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40051-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40052-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40052-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

Primary antibody

F40053-0.08ML 0.08 ml
EUR 157.25
Description: Polyclonal (rabbit origin)

Primary antibody

F40053-0.4ML 0.4 ml
EUR 339.15
Description: Polyclonal (rabbit origin)

A patients with HCC. bioinformatics analysis performed to find candidate somatic protein-altering mutations. Eighty validated deleterious mutations and 59 genes were reported associated mutations in HBV HCCS for the first time here.