Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry.

association (GWA) studies have identified 19 independent genome loci general risk for endometriosis. Most variants of GWA is non-coding and the gene responsible for the association signal has not been identified. Here, we aimed to assess the potential role of protein-modified variant of endometriosis using exome genotyping arrays in 7164 cases and 21 005 controls, and a set of replication of 1840 cases and 129 016 controls of European descent.

The results in the discovery of samples identified significant evidence for association with coding variants in the variant (rs1801232-CUBN) and gene-level (CIITA and PARP4) meta-analysis, but this did not last replication. In the combined analysis, there is a genome-wide significant evidence for rs13394619 (P = 2.3 × 10-9) in GREB1 at 2p25.1 – GWA loci previously identified in a meta-analysis of European and Japanese samples.

Despite considerable power, our results do not identify variants of a protein-modifying (MAF >> 0.01) with moderate or large effect sizes in endometriosis, although this variant may be present in non-European populations or in high-risk families. The results indicate continued efforts should focus on the discovery of a large number of surgical cases genotype-confirmed endometriosis and controls, and / or high-risk families sequencing to identify rare variants new to provide greater insight into the molecular pathogenesis of the disease.


The role of the base excision repair (BER) gene on the Philadelphia-negative (PN) -myeloproliferative neoplasms (MPNs) susceptibility genotypes were evaluated with eight polymorphisms [apurinic / apyrimidinic endodeoxyribonuclease 1, mutY glikosilase DNA, previously mutY homolog (E. coli) (MUTYH) 8-oxoguanine DNA glikosilase 1, poly (ADP-ribose) polymerase (PARP) 1, PARP4 and X-ray repair cross complement 1 (XRCC1)] in a case-control study involving 133 patients of Caucasian Portuguese. The results did not reveal a correlation between polymorphisms of individual BER and PN-MPNs when considered as a whole.

However, stratification for essential thrombocythaemia disclose i) the effect of the limit / tendency to increased risk when carrying at least one variant allele for XRCC1_399 single nucleotide polymorphism (SNP); ii) reduction in risk for the Janus kinase 2-positive patients carrying at least one variant allele of SNP XRCC1_399; and iii) reduced risk in women who carry at least one variant allele of SNP MUTYH.

Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry.
Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry.

Known and novel mutations in cancer susceptibility genes in Young Patients with Pancreatic Cancer.

BACKGROUND
Pancreatic cancer is the fourth most common cause of cancer deaths, globally. It has a poor prognosis and is usually diagnosed at later stages when the tumor resection is not possible. Heritability for pancreatic cancer are relatively high and clinically significant.


METHOD
A group of 24 patients with pancreatic cancer at a young age at onset, of the main referral hospital in Tehran University of Medical Sciences were screened for mutations in 710 cancer relevant genes using next-generation sequencing technology.

RESULTS
Two patients had pathogenic mutations in genes known pancreatic cancer susceptibility, BRCA1 / 2 Two other patients also have potentially pathogenic mutations in two new gene candidates including PARP4 and EXO1.


CONCLUSION
BRCA1 / 2 genes most frequently mutated pancreatic cancer susceptibility genes that should be considered in all cases of pancreatic cancer at a young age at onset or a family history of cancer. PARP4 and EXO1 also is a potential candidate gene for susceptibility to pancreatic cancer.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

DLR-PARP4-Hu-48T 48T
EUR 517
Description: A sandwich quantitative ELISA assay kit for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in samples from tissue homogenates or other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

DLR-PARP4-Hu-96T 96T
EUR 673
Description: A sandwich quantitative ELISA assay kit for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in samples from tissue homogenates or other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

RDR-PARP4-Hu-48Tests 48 Tests
EUR 544

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

RDR-PARP4-Hu-96Tests 96 Tests
EUR 756

PARP4 Antibody

1-CSB-PA007321
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PARP4. Recognizes PARP4 from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000

PARP4 Antibody

1-CSB-PA947926
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against PARP4. Recognizes PARP4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

PARP4 Antibody

37796-100ul 100ul
EUR 252

PARP4 siRNA

20-abx927766
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

PARP4 Antibody

DF2386 200ul
EUR 304
Description: PARP4 antibody detects endogenous levels of total PARP4.

PARP4 Antibody

ABD2386 100 ug
EUR 438

PARP4 antibody

10R-1680 100 ug
EUR 512
Description: Mouse monoclonal PARP4 antibody

PARP4 antibody

70R-33845 100 ug
EUR 327
Description: Rabbit polyclonal PARP4 antibody

anti-PARP4

YF-PA23186 50 ul
EUR 334
Description: Mouse polyclonal to PARP4

Anti-PARP4 antibody

STJ119167 100 µl
EUR 277

Anti-PARP4 antibody

STJ110641 100 µl
EUR 277
Description: This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.

PARP4 Rabbit pAb

A16749-100ul 100 ul
EUR 308

PARP4 Rabbit pAb

A16749-200ul 200 ul
EUR 459

PARP4 Rabbit pAb

A16749-20ul 20 ul
EUR 183

PARP4 Rabbit pAb

A16749-50ul 50 ul
EUR 223

PARP4 Rabbit pAb

A8343-100ul 100 ul
EUR 308

PARP4 Rabbit pAb

A8343-200ul 200 ul
EUR 459

PARP4 Rabbit pAb

A8343-20ul 20 ul
EUR 183

PARP4 Rabbit pAb

A8343-50ul 50 ul
EUR 223

PARP4 Conjugated Antibody

C37796 100ul
EUR 397

PARP4 Blocking Peptide

DF2386-BP 1mg
EUR 195

Human PARP4 shRNA Plasmid

20-abx950100
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

PARP4 ELISA KIT|Human

EF007039 96 Tests
EUR 689

PARP4 ELISA Kit (Human) (OKDD00456)

OKDD00456 96 Wells
EUR 975
Description: Description of target: This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.;Species reactivity: Human;Application: ;Assay info: Quantitative Sandwich ELISA;Sensitivity: < 0.061 ng/mL

PARP4 ELISA Kit (Human) (OKCD08347)

OKCD08347 96 Wells
EUR 975
Description: Description of target: This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.061ng/mL

PARP4 ORF Vector (Human) (pORF)

ORF027423 1.0 ug DNA
EUR 405

Parp4 ORF Vector (Mouse) (pORF)

ORF053400 1.0 ug DNA
EUR 1572

PARP4 sgRNA CRISPR Lentivector set (Human)

K1595801 3 x 1.0 ug
EUR 339

Parp4 sgRNA CRISPR Lentivector set (Mouse)

K4858201 3 x 1.0 ug
EUR 339

PARP4-AS1 ORF Vector (Human) (pORF)

ORF027424 1.0 ug DNA Ask for price

Recombinant Poly ADP Ribose Polymerase 4 (PARP4)

4-RPC984Hu01
  • EUR 458.40
  • EUR 226.00
  • EUR 1444.00
  • EUR 548.00
  • EUR 996.00
  • EUR 370.00
  • EUR 3460.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Poly ADP Ribose Polymerase 4 expressed in: E.coli

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx128291
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx119585
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx322903
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx339348
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx147654-100ug 100 ug
EUR 439

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx006130
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx174132
  • EUR 857.00
  • EUR 439.00
  • 1 mg
  • 200 ug

PARP4 sgRNA CRISPR Lentivector (Human) (Target 1)

K1595802 1.0 ug DNA
EUR 154

PARP4 sgRNA CRISPR Lentivector (Human) (Target 2)

K1595803 1.0 ug DNA
EUR 154

PARP4 sgRNA CRISPR Lentivector (Human) (Target 3)

K1595804 1.0 ug DNA
EUR 154

Parp4 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4858202 1.0 ug DNA
EUR 154

Parp4 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4858203 1.0 ug DNA
EUR 154

Parp4 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4858204 1.0 ug DNA
EUR 154

PARP4 3'UTR GFP Stable Cell Line

TU067410 1.0 ml
EUR 1394

PARP4 Protein Vector (Human) (pPB-C-His)

PV109690 500 ng Ask for price

PARP4 Protein Vector (Human) (pPB-N-His)

PV109691 500 ng Ask for price

PARP4 Protein Vector (Human) (pPM-C-HA)

PV109692 500 ng Ask for price

PARP4 Protein Vector (Human) (pPM-C-His)

PV109693 500 ng Ask for price

PARP4 Protein Vector (Mouse) (pPB-C-His)

PV213598 500 ng
EUR 3252

PARP4 Protein Vector (Mouse) (pPB-N-His)

PV213599 500 ng
EUR 3252

PARP4 Protein Vector (Mouse) (pPM-C-HA)

PV213600 500 ng
EUR 3252

PARP4 Protein Vector (Mouse) (pPM-C-His)

PV213601 500 ng
EUR 3252

PARP4 3'UTR Luciferase Stable Cell Line

TU017410 1.0 ml
EUR 1394

Parp4 3'UTR Luciferase Stable Cell Line

TU115923 1.0 ml Ask for price

Parp4 3'UTR GFP Stable Cell Line

TU165923 1.0 ml Ask for price

Human Poly ADP Ribose Polymerase 4 (PARP4) Protein

20-abx166526
  • EUR 648.00
  • EUR 272.00
  • EUR 1943.00
  • EUR 759.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

SEC984Hu-10x96wellstestplate 10x96-wells test plate
EUR 4731.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in Tissue homogenates and other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

SEC984Hu-1x48wellstestplate 1x48-wells test plate
EUR 477.3
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in Tissue homogenates and other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

SEC984Hu-1x96wellstestplate 1x96-wells test plate
EUR 639
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in Tissue homogenates and other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

SEC984Hu-5x96wellstestplate 5x96-wells test plate
EUR 2575.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in Tissue homogenates and other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

4-SEC984Hu
  • EUR 4782.00
  • EUR 2526.00
  • EUR 640.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human)

4-PAC984Hu01
  • EUR 247.00
  • EUR 2510.00
  • EUR 625.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4)

Human Poly ADP Ribose Polymerase 4 (PARP4) CLIA Kit

20-abx494031
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Pig Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx360853-96tests 96 tests
EUR 825

Rabbit Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx363456-96tests 96 tests
EUR 825

Chicken Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx355780-96tests 96 tests
EUR 825

Monkey Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx358874-96tests 96 tests
EUR 825

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

20-abx152651
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Poly ADP Ribose Polymerase 4 (PARP4) CLIA Kit

abx197521-96tests 96 tests
EUR 825

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx252901-96tests 96 tests
EUR 707

Human PARP4(Poly ADP Ribose Polymerase 4) ELISA Kit

EH3510 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human Poly [ADP- ribose] polymerase 4, PARP4 ELISA KIT

ELI-12310h 96 Tests
EUR 824

PARP4-AS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV739631 1.0 ug DNA Ask for price

PARP4-AS1 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV739635 1.0 ug DNA Ask for price

PARP4-AS1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV739636 1.0 ug DNA Ask for price

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), APC

4-PAC984Hu01-APC
  • EUR 345.00
  • EUR 3275.00
  • EUR 912.00
  • EUR 440.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with APC.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), Biotinylated

4-PAC984Hu01-Biotin
  • EUR 311.00
  • EUR 2460.00
  • EUR 727.00
  • EUR 381.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with Biotin.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), Cy3

4-PAC984Hu01-Cy3
  • EUR 419.00
  • EUR 4325.00
  • EUR 1175.00
  • EUR 545.00
  • EUR 251.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with Cy3.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), FITC

4-PAC984Hu01-FITC
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with FITC.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), HRP

4-PAC984Hu01-HRP
  • EUR 316.00
  • EUR 2855.00
  • EUR 807.00
  • EUR 398.00
  • EUR 206.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with HRP.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), PE

4-PAC984Hu01-PE
  • EUR 296.00
  • EUR 2640.00
  • EUR 750.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with PE.

ELISA kit for Human PARP4 (Poly ADP Ribose Polymerase 4)

E-EL-H2420 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Human PARP4 (Poly ADP Ribose Polymerase 4) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Human PARP4 (Poly ADP Ribose Polymerase 4)

E-CL-H1422 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Human PARP4 (Poly ADP Ribose Polymerase 4) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human PARP4 (Poly ADP Ribose Polymerase 4)

ELK3564 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Poly ADP Ribose Polymerase 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

PARP4 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K1595805 3 x 1.0 ug
EUR 376

Parp4 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K4858205 3 x 1.0 ug
EUR 376

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), APC-Cy7

4-PAC984Hu01-APC-Cy7
  • EUR 571.00
  • EUR 6430.00
  • EUR 1705.00
  • EUR 760.00
  • EUR 319.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with APC-Cy7.

PARP4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K1595806 1.0 ug DNA
EUR 167

PARP4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K1595807 1.0 ug DNA
EUR 167

PARP4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K1595808 1.0 ug DNA
EUR 167

Parp4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)

K4858206 1.0 ug DNA
EUR 167

Parp4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

K4858207 1.0 ug DNA
EUR 167

Parp4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)

K4858208 1.0 ug DNA
EUR 167

PARP4-AS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV739632 1.0 ug DNA Ask for price

PARP4-AS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV739633 1.0 ug DNA Ask for price

PARP4-AS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV739634 1.0 ug DNA Ask for price

Identifying hereditary cases of pancreatic cancer will help to offer more targeted treatments for patients and also to prevent cancer in family members who may be carriers of the mutation.