Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry.

association (GWA) studies have identified 19 independent genome loci general risk for endometriosis. Most variants of GWA is non-coding and the gene responsible for the association signal has not been identified. Here, we aimed to assess the potential role of protein-modified variant of endometriosis using exome genotyping arrays in 7164 cases and 21 005 controls, and a set of replication of 1840 cases and 129 016 controls of European descent.

The results in the discovery of samples identified significant evidence for association with coding variants in the variant (rs1801232-CUBN) and gene-level (CIITA and PARP4) meta-analysis, but this did not last replication. In the combined analysis, there is a genome-wide significant evidence for rs13394619 (P = 2.3 × 10-9) in GREB1 at 2p25.1 – GWA loci previously identified in a meta-analysis of European and Japanese samples.

Despite considerable power, our results do not identify variants of a protein-modifying (MAF >> 0.01) with moderate or large effect sizes in endometriosis, although this variant may be present in non-European populations or in high-risk families. The results indicate continued efforts should focus on the discovery of a large number of surgical cases genotype-confirmed endometriosis and controls, and / or high-risk families sequencing to identify rare variants new to provide greater insight into the molecular pathogenesis of the disease.


The role of the base excision repair (BER) gene on the Philadelphia-negative (PN) -myeloproliferative neoplasms (MPNs) susceptibility genotypes were evaluated with eight polymorphisms [apurinic / apyrimidinic endodeoxyribonuclease 1, mutY glikosilase DNA, previously mutY homolog (E. coli) (MUTYH) 8-oxoguanine DNA glikosilase 1, poly (ADP-ribose) polymerase (PARP) 1, PARP4 and X-ray repair cross complement 1 (XRCC1)] in a case-control study involving 133 patients of Caucasian Portuguese. The results did not reveal a correlation between polymorphisms of individual BER and PN-MPNs when considered as a whole.

However, stratification for essential thrombocythaemia disclose i) the effect of the limit / tendency to increased risk when carrying at least one variant allele for XRCC1_399 single nucleotide polymorphism (SNP); ii) reduction in risk for the Janus kinase 2-positive patients carrying at least one variant allele of SNP XRCC1_399; and iii) reduced risk in women who carry at least one variant allele of SNP MUTYH.

Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry.
Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry.

Known and novel mutations in cancer susceptibility genes in Young Patients with Pancreatic Cancer.

BACKGROUND
Pancreatic cancer is the fourth most common cause of cancer deaths, globally. It has a poor prognosis and is usually diagnosed at later stages when the tumor resection is not possible. Heritability for pancreatic cancer are relatively high and clinically significant.


METHOD
A group of 24 patients with pancreatic cancer at a young age at onset, of the main referral hospital in Tehran University of Medical Sciences were screened for mutations in 710 cancer relevant genes using next-generation sequencing technology.

RESULTS
Two patients had pathogenic mutations in genes known pancreatic cancer susceptibility, BRCA1 / 2 Two other patients also have potentially pathogenic mutations in two new gene candidates including PARP4 and EXO1.


CONCLUSION
BRCA1 / 2 genes most frequently mutated pancreatic cancer susceptibility genes that should be considered in all cases of pancreatic cancer at a young age at onset or a family history of cancer. PARP4 and EXO1 also is a potential candidate gene for susceptibility to pancreatic cancer.

PARP4 Antibody

37796-100ul 100ul
EUR 302.4

PARP4 antibody

70R-33845 100 ug
EUR 392.4
Description: Rabbit polyclonal PARP4 antibody

PARP4 Antibody

ABD2386 100 ug
EUR 525.6

PARP4 Antibody

DF2386 200ul
EUR 420

PARP4 Antibody

1-CSB-PA947926
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against PARP4. Recognizes PARP4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

PARP4 Antibody

1-CSB-PA007321
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against PARP4. Recognizes PARP4 from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000

PARP4 Rabbit pAb

A16749-100ul 100 ul
EUR 369.6

PARP4 Rabbit pAb

A16749-200ul 200 ul
EUR 550.8

PARP4 Rabbit pAb

A16749-20ul 20 ul
EUR 219.6

PARP4 Rabbit pAb

A16749-50ul 50 ul
EUR 267.6

PARP4 Rabbit pAb

A8343-100ul 100 ul
EUR 369.6

PARP4 Rabbit pAb

A8343-200ul 200 ul
EUR 550.8

PARP4 Rabbit pAb

A8343-20ul 20 ul
EUR 219.6

PARP4 Rabbit pAb

A8343-50ul 50 ul
EUR 267.6

PARP4 Blocking Peptide

DF2386-BP 1mg
EUR 234

PARP4 Conjugated Antibody

C37796 100ul
EUR 476.4

PARP4 ELISA KIT|Human

EF007039 96 Tests
EUR 826.8

Human PARP4 shRNA Plasmid

20-abx950100
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

PARP4 ORF Vector (Human) (pORF)

ORF027423 1.0 ug DNA
EUR 486

Parp4 ORF Vector (Mouse) (pORF)

ORF053400 1.0 ug DNA
EUR 1886.4

PARP4 ELISA Kit (Human) (OKCD08347)

OKCD08347 96 Wells
EUR 1170
Description: Description of target: This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.061ng/mL

PARP4 ELISA Kit (Human) (OKDD00456)

OKDD00456 96 Wells
EUR 1170
Description: Description of target: This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.;Species reactivity: Human;Application: ;Assay info: Quantitative Sandwich ELISA;Sensitivity: < 0.061 ng/mL

PARP4, His-GST-Tag Recombinant

11394 50 µg
EUR 280
Description: Recombinant human PARP4 (poly(ADP-ribose) polymerase family member 4), encompassing amino acids 2-700. This construct contains an N-terminal His-tag (6xHis) followed by a GST-tag and a Thrombin Cleavage sight to facilitate removal of the GST-tag. This recombinant protein was affinity purified.  

PARP4-AS1 ORF Vector (Human) (pORF)

ORF027424 1.0 ug DNA Ask for price

Parp4 sgRNA CRISPR Lentivector set (Mouse)

K4858201 3 x 1.0 ug
EUR 406.8

PARP4 sgRNA CRISPR Lentivector set (Human)

K1595801 3 x 1.0 ug
EUR 406.8

Parp4 3'UTR GFP Stable Cell Line

TU165923 1.0 ml Ask for price

PARP4 3'UTR GFP Stable Cell Line

TU067410 1.0 ml
EUR 1672.8

PARP4 Protein Vector (Human) (pPM-C-HA)

PV109692 500 ng Ask for price

PARP4 Protein Vector (Mouse) (pPM-C-HA)

PV213600 500 ng
EUR 3902.4

PARP4 Protein Vector (Human) (pPB-C-His)

PV109690 500 ng Ask for price

PARP4 Protein Vector (Human) (pPB-N-His)

PV109691 500 ng Ask for price

PARP4 Protein Vector (Human) (pPM-C-His)

PV109693 500 ng Ask for price

PARP4 Protein Vector (Mouse) (pPB-C-His)

PV213598 500 ng
EUR 3902.4

PARP4 Protein Vector (Mouse) (pPB-N-His)

PV213599 500 ng
EUR 3902.4

PARP4 Protein Vector (Mouse) (pPM-C-His)

PV213601 500 ng
EUR 3902.4

Parp4 3'UTR Luciferase Stable Cell Line

TU115923 1.0 ml Ask for price

PARP4 3'UTR Luciferase Stable Cell Line

TU017410 1.0 ml
EUR 1672.8

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx174132
  • EUR 1028.40
  • EUR 526.80
  • 1 mg
  • 200 ug

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx119585
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx147654-100ug 100 ug
EUR 526.8

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx128291
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx322903
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx339348
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx006130
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Parp4 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4858202 1.0 ug DNA
EUR 184.8

Parp4 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4858203 1.0 ug DNA
EUR 184.8

Parp4 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4858204 1.0 ug DNA
EUR 184.8

PARP4 sgRNA CRISPR Lentivector (Human) (Target 1)

K1595802 1.0 ug DNA
EUR 184.8

PARP4 sgRNA CRISPR Lentivector (Human) (Target 2)

K1595803 1.0 ug DNA
EUR 184.8

PARP4 sgRNA CRISPR Lentivector (Human) (Target 3)

K1595804 1.0 ug DNA
EUR 184.8

Recombinant Poly ADP Ribose Polymerase 4 (PARP4)

4-RPC984Hu01
  • EUR 550.08
  • EUR 271.20
  • EUR 1732.80
  • EUR 657.60
  • EUR 1195.20
  • EUR 444.00
  • EUR 4152.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Poly ADP Ribose Polymerase 4 expressed in: E.coli

Human Poly ADP Ribose Polymerase 4 (PARP4) Protein

20-abx166526
  • EUR 777.60
  • EUR 326.40
  • EUR 2331.60
  • EUR 910.80
  • EUR 560.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Pig Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx360853-96tests 96 tests
EUR 990

Human Poly ADP Ribose Polymerase 4 (PARP4) CLIA Kit

abx197521-96tests 96 tests
EUR 990

Human Poly ADP Ribose Polymerase 4 (PARP4) CLIA Kit

20-abx494031
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx252901-96tests 96 tests
EUR 848.4

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

DLR-PARP4-Hu-48T 48T
EUR 620.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in samples from tissue homogenates or other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

DLR-PARP4-Hu-96T 96T
EUR 807.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in samples from tissue homogenates or other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

20-abx152651
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human PARP4(Poly ADP Ribose Polymerase 4) ELISA Kit

EH3510 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human Poly [ADP- ribose] polymerase 4, PARP4 ELISA KIT

ELI-12310h 96 Tests
EUR 988.8

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

RD-PARP4-Hu-48Tests 48 Tests
EUR 625.2

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

RD-PARP4-Hu-96Tests 96 Tests
EUR 867.6

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

RDR-PARP4-Hu-48Tests 48 Tests
EUR 652.8

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

RDR-PARP4-Hu-96Tests 96 Tests
EUR 907.2

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

SEC984Hu-10x96wellstestplate 10x96-wells test plate
EUR 5677.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in Tissue homogenates and other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

SEC984Hu-1x48wellstestplate 1x48-wells test plate
EUR 572.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in Tissue homogenates and other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

SEC984Hu-1x96wellstestplate 1x96-wells test plate
EUR 766.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in Tissue homogenates and other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

SEC984Hu-5x96wellstestplate 5x96-wells test plate
EUR 3090.6
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in Tissue homogenates and other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

4-SEC984Hu
  • EUR 5738.40
  • EUR 3031.20
  • EUR 768.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

RDR-PARP4-Hu-48T 48T
EUR 475.34
Description: tissue homogenates and other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

RDR-PARP4-Hu-96T 96T
EUR 679.04
Description: tissue homogenates and other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

RD-PARP4-Hu-48T 48T
EUR 452.7
Description: tissue homogenates and other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

RD-PARP4-Hu-96T 96T
EUR 646.7
Description: tissue homogenates and other biological fluids.

Monkey Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx358874-96tests 96 tests
EUR 990

Rabbit Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx363456-96tests 96 tests
EUR 990

Chicken Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx355780-96tests 96 tests
EUR 990

PARP4-AS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV739631 1.0 ug DNA Ask for price

PARP4-AS1 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV739635 1.0 ug DNA Ask for price

CLIA kit for Human PARP4 (Poly ADP Ribose Polymerase 4)

E-CL-H1422 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human PARP4 (Poly ADP Ribose Polymerase 4) in samples from Serum, Plasma, Cell supernatant

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human)

4-PAC984Hu01
  • EUR 296.40
  • EUR 3012.00
  • EUR 750.00
  • EUR 372.00
  • EUR 256.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4)

PARP4-AS1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV739636 1.0 ug DNA Ask for price

ELISA kit for Human PARP4 (Poly ADP Ribose Polymerase 4)

E-EL-H2420 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human PARP4 (Poly ADP Ribose Polymerase 4) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human PARP4 (Poly ADP Ribose Polymerase 4)

ELK3564 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Poly ADP Ribose Polymerase 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Parp4 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K4858205 3 x 1.0 ug
EUR 451.2

PARP4 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K1595805 3 x 1.0 ug
EUR 451.2

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), PE

4-PAC984Hu01-PE
  • EUR 355.20
  • EUR 3168.00
  • EUR 900.00
  • EUR 446.40
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with PE.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), APC

4-PAC984Hu01-APC
  • EUR 414.00
  • EUR 3930.00
  • EUR 1094.40
  • EUR 528.00
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with APC.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), Cy3

4-PAC984Hu01-Cy3
  • EUR 502.80
  • EUR 5190.00
  • EUR 1410.00
  • EUR 654.00
  • EUR 301.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with Cy3.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), HRP

4-PAC984Hu01-HRP
  • EUR 379.20
  • EUR 3426.00
  • EUR 968.40
  • EUR 477.60
  • EUR 247.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with HRP.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), FITC

4-PAC984Hu01-FITC
  • EUR 355.20
  • EUR 3168.00
  • EUR 900.00
  • EUR 446.40
  • EUR 234.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with FITC.

Parp4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)

K4858206 1.0 ug DNA
EUR 200.4

Parp4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

K4858207 1.0 ug DNA
EUR 200.4

Parp4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)

K4858208 1.0 ug DNA
EUR 200.4

PARP4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K1595806 1.0 ug DNA
EUR 200.4

PARP4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K1595807 1.0 ug DNA
EUR 200.4

PARP4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K1595808 1.0 ug DNA
EUR 200.4

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), Biotinylated

4-PAC984Hu01-Biotin
  • EUR 373.20
  • EUR 2952.00
  • EUR 872.40
  • EUR 457.20
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with Biotin.

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody (Human), APC-Cy7

4-PAC984Hu01-APC-Cy7
  • EUR 685.20
  • EUR 7716.00
  • EUR 2046.00
  • EUR 912.00
  • EUR 382.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Poly ADP Ribose Polymerase 4 (PARP4). This antibody is labeled with APC-Cy7.

PARP4-AS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV739632 1.0 ug DNA Ask for price

PARP4-AS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV739633 1.0 ug DNA Ask for price

PARP4-AS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV739634 1.0 ug DNA Ask for price

anti-PARP4

YF-PA23186 50 ul
EUR 400.8
Description: Mouse polyclonal to PARP4

Parp16/ Rat Parp16 ELISA Kit

ELI-22008r 96 Tests
EUR 1063.2

Parp1/ Rat Parp1 ELISA Kit

ELI-03101r 96 Tests
EUR 1063.2

PARPtrap™ Combo Assay Kit for PARP1 and PARP2

78317 384 rxns.
EUR 3000
Description: The PARPtrap™ Combo Assay Kit for PARP1 and PARP2 is a kit designed to measure DNA complex formations of PARP1 and PARP2 enzymes in a high throughput screening assay using fluorescence polarization (FP). The key to the PARPtrap™ Combo Assay Kit are the fluorescent-labeled DNA probes recognized by PARP1 and PARP2. In the absence of ribosylation, PARP1/2 binds to the DNA fluorescent probe, forming a large complex and resulting in the emission of highly polarized light. However, after autoribosylation, PARP1/2 dissociates from the oligonucleotide duplex, which then rotates freely, emitting less polarized light (Fig. 1). Addition of a PARP inhibitor results in trapping of PARP1/2 to the fluorescent-labeled DNA, and increases the FP signal in a dose dependent manner.The combo kit is particularly useful to directly and specifically compare, in a single assay, the effect and potency of a compound on PARP1 and PARP2. The PARPtrap™ Combo Assay Kit for PARP1 and PARP2 is a homogeneous fluorescence polarization assay. The FP signal is measured using a fluorescent microplate reader capable of measuring fluorescence polarization.

Mono [ADP-Ribose] Polymerase PARP16 (PARP16) Antibody

abx032790-400ul 400 ul
EUR 627.6

Mono [ADP-Ribose] Polymerase PARP16 (PARP16) Antibody

abx032790-80l 80 µl
EUR 343.2

Mono [ADP-Ribose] Polymerase PARP16 (PARP16) Antibody

abx340062-100ug 100 ug
EUR 469.2

PARP16 siRNA

20-abx903846
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PARP10 siRNA

20-abx927751
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PARP11 siRNA

20-abx927752
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PARP11 siRNA

20-abx927753
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PARP12 siRNA

20-abx927754
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PARP12 siRNA

20-abx927755
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PARP14 siRNA

20-abx927756
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PARP14 siRNA

20-abx927757
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PARP15 siRNA

20-abx927758
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PARP16 siRNA

20-abx927759
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PARP16 siRNA

20-abx927760
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

PARP11, GST-tag

80511 10 µg
EUR 490
Description: Human PARP11 (GenBank Accession No. NM_020367), a.a. 8-338 (end) with N-terminal GST-tag, MW = 65.6 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

PARP15, GST-tag

80517 10 µg
EUR 490
Description: Human poly (ADP-ribose) polymerase family, member 15 (PARP15) (GenBank Accession No. NM_152615, var.2), a.a. 221-444(end) with N-terminal GST-tag, MW = 52.5 kDa, expressed in an E. coli expression system.

PARP12 Peptide

43-116P 0.1 mg
EUR 405.6

PARP12 Rabbit pAb

A14317-100ul 100 ul
EUR 369.6

PARP12 Rabbit pAb

A14317-200ul 200 ul
EUR 550.8

PARP12 Rabbit pAb

A14317-20ul 20 ul
EUR 219.6

PARP12 Rabbit pAb

A14317-50ul 50 ul
EUR 267.6

PARP10 Rabbit pAb

A12815-100ul 100 ul
EUR 369.6

PARP10 Rabbit pAb

A12815-200ul 200 ul
EUR 550.8

PARP10 Rabbit pAb

A12815-20ul 20 ul
EUR 219.6

PARP10 Rabbit pAb

A12815-50ul 50 ul
EUR 267.6

PARP16 antibody

10R-5157 100 ul
EUR 871.2
Description: Mouse monoclonal PARP16 antibody

PARP16 antibody

10R-5158 100 ul
EUR 829.2
Description: Mouse monoclonal PARP16 antibody

PARP10 Antibody

37799-100ul 100ul
EUR 302.4

PARP11 antibody

70R-19116 50 ul
EUR 522
Description: Rabbit polyclonal PARP11 antibody

PARP15 antibody

70R-19117 50 ul
EUR 522
Description: Rabbit polyclonal PARP15 antibody

PARP11 antibody

70R-1285 100 ug
EUR 452.4
Description: Rabbit polyclonal PARP11 antibody

PARP16 antibody

70R-6276 50 ug
EUR 560.4
Description: Rabbit polyclonal PARP16 antibody

PARP16 antibody

70R-6277 50 ug
EUR 560.4
Description: Rabbit polyclonal PARP16 antibody

PARP10 antibody

70R-8550 50 ug
EUR 560.4
Description: Affinity purified rabbit polyclonal PARP10 antibody

PARP10 antibody

70R-8551 50 ug
EUR 560.4
Description: Affinity purified rabbit polyclonal PARP10 antibody

Identifying hereditary cases of pancreatic cancer will help to offer more targeted treatments for patients and also to prevent cancer in family members who may be carriers of the mutation.