Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry.

association (GWA) studies have identified 19 independent genome loci general risk for endometriosis. Most variants of GWA is non-coding and the gene responsible for the association signal has not been identified. Here, we aimed to assess the potential role of protein-modified variant of endometriosis using exome genotyping arrays in 7164 cases and 21 005 controls, and a set of replication of 1840 cases and 129 016 controls of European descent.

The results in the discovery of samples identified significant evidence for association with coding variants in the variant (rs1801232-CUBN) and gene-level (CIITA and PARP4) meta-analysis, but this did not last replication. In the combined analysis, there is a genome-wide significant evidence for rs13394619 (P = 2.3 × 10-9) in GREB1 at 2p25.1 – GWA loci previously identified in a meta-analysis of European and Japanese samples.

Despite considerable power, our results do not identify variants of a protein-modifying (MAF >> 0.01) with moderate or large effect sizes in endometriosis, although this variant may be present in non-European populations or in high-risk families. The results indicate continued efforts should focus on the discovery of a large number of surgical cases genotype-confirmed endometriosis and controls, and / or high-risk families sequencing to identify rare variants new to provide greater insight into the molecular pathogenesis of the disease.


The role of the base excision repair (BER) gene on the Philadelphia-negative (PN) -myeloproliferative neoplasms (MPNs) susceptibility genotypes were evaluated with eight polymorphisms [apurinic / apyrimidinic endodeoxyribonuclease 1, mutY glikosilase DNA, previously mutY homolog (E. coli) (MUTYH) 8-oxoguanine DNA glikosilase 1, poly (ADP-ribose) polymerase (PARP) 1, PARP4 and X-ray repair cross complement 1 (XRCC1)] in a case-control study involving 133 patients of Caucasian Portuguese. The results did not reveal a correlation between polymorphisms of individual BER and PN-MPNs when considered as a whole.

However, stratification for essential thrombocythaemia disclose i) the effect of the limit / tendency to increased risk when carrying at least one variant allele for XRCC1_399 single nucleotide polymorphism (SNP); ii) reduction in risk for the Janus kinase 2-positive patients carrying at least one variant allele of SNP XRCC1_399; and iii) reduced risk in women who carry at least one variant allele of SNP MUTYH.

Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry.
Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry.

Known and novel mutations in cancer susceptibility genes in Young Patients with Pancreatic Cancer.

BACKGROUND
Pancreatic cancer is the fourth most common cause of cancer deaths, globally. It has a poor prognosis and is usually diagnosed at later stages when the tumor resection is not possible. Heritability for pancreatic cancer are relatively high and clinically significant.


METHOD
A group of 24 patients with pancreatic cancer at a young age at onset, of the main referral hospital in Tehran University of Medical Sciences were screened for mutations in 710 cancer relevant genes using next-generation sequencing technology.

RESULTS
Two patients had pathogenic mutations in genes known pancreatic cancer susceptibility, BRCA1 / 2 Two other patients also have potentially pathogenic mutations in two new gene candidates including PARP4 and EXO1.


CONCLUSION
BRCA1 / 2 genes most frequently mutated pancreatic cancer susceptibility genes that should be considered in all cases of pancreatic cancer at a young age at onset or a family history of cancer. PARP4 and EXO1 also is a potential candidate gene for susceptibility to pancreatic cancer.

PARP4 Antibody

8C13099 50ug
EUR 368
Description: PARP4 Antibody

PARP4 antibody

10R-1680 100 ug
EUR 614.4
Description: Mouse monoclonal PARP4 antibody

PARP4 Antibody

37796 100ul
EUR 319

PARP4 Antibody

37796-100ul 100ul
EUR 302.4

PARP4 Antibody

1-CSB-PA947926
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  • 100ul
  • 50ul
Description: A polyclonal antibody against PARP4. Recognizes PARP4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

PARP4 Antibody

E037796 100μg/100μl
EUR 255
Description: Available in various conjugation types.

PARP4 Antibody

E11-13099C 100μg
EUR 225
Description: Available in various conjugation types.

PARP4 Antibody

DF2386 200ul
EUR 420

PARP4 Antibody

DF2386-100ul 100ul
EUR 280

PARP4 Antibody

DF2386-200ul 200ul
EUR 350

PARP4 Antibody

E98343 100ul
EUR 255
Description: Available in various conjugation types.

PARP4 antibody

70R-33845 100 ug
EUR 294
Description: Rabbit polyclonal PARP4 antibody

PARP4 Antibody

1-CSB-PA007321
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  • 100ug
  • 50ug
Description: A polyclonal antibody against PARP4. Recognizes PARP4 from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000

PARP4 Rabbit pAb

A8343-100ul 100 ul
EUR 369.6

PARP4 Rabbit pAb

A8343-200ul 200 ul
EUR 550.8

PARP4 Rabbit pAb

A8343-20ul 20 ul
EUR 219.6

PARP4 Rabbit pAb

A8343-50ul 50 ul
EUR 267.6

PARP4 Rabbit pAb

E2508343 100ul
EUR 225
Description: Available in various conjugation types.

PARP4 Rabbit pAb

A16749-100ul 100 ul
EUR 369.6

PARP4 Rabbit pAb

A16749-200ul 200 ul
EUR 550.8

PARP4 Rabbit pAb

A16749-20ul 20 ul
EUR 219.6

PARP4 Rabbit pAb

A16749-50ul 50 ul
EUR 267.6

PARP4 Blocking Peptide

DF2386-BP 1mg
EUR 234

PARP4 Polyclonal Antibody

E916749 100ul
EUR 225
Description: Available in various conjugation types.

PARP4 Conjugated Antibody

C37796 100ul
EUR 476.4

PARP4 Polyclonal Antibody

E-AB-91627-120uL 120uL
EUR 320
Description: Unconjugated

PARP4 Polyclonal Antibody

E-AB-91627-200uL 200uL
EUR 530
Description: Unconjugated

PARP4 Polyclonal Antibody

E-AB-91627-60uL 60uL
EUR 200
Description: Unconjugated

PARP4 Polyclonal Antibody

E-AB-91627-each each Ask for price
Description: Unconjugated

Recombinant Human Protein mono-ADP-ribosyltransferase PARP4 (PARP4), partial

CSB-EP892136HU 8890 mg Ask for price

PARP4 ELISA KIT|Human

EF007039 96 Tests
EUR 826.8

PARP4 (untagged)-Human poly (ADP-ribose) polymerase family, member 4 (PARP4)

SC116119 10 µg Ask for price

Human PARP4 shRNA Plasmid

20-abx950100
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  • 150 µg
  • 300 µg

OACD06303-1ML - PARP4 Antibody

OACD06303-1ML 1ml
EUR 669

OAAN02690-50UL - PARP4 Antibody

OAAN02690-50UL 50ul
EUR 149

PARP4 Rabbit Polyclonal Antibody

54277 100ul
EUR 439

OACD06303-100UL - PARP4 Antibody

OACD06303-100UL 100ul
EUR 199

OAAF03061-100UG - PARP4 Antibody

OAAF03061-100UG 100ug
EUR 329

OAAN02690-100UL - PARP4 Antibody

OAAN02690-100UL 100ul
EUR 249

OAAN02690-200UL - PARP4 Antibody

OAAN02690-200UL 200ul
EUR 389

PARP4 Rabbit Polyclonal Antibody

E10G12021 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PARP4 (GFP-tagged) - Human poly (ADP-ribose) polymerase family, member 4 (PARP4)

RG220444 10 µg Ask for price

Parp4 (untagged) - Mouse poly (ADP-ribose) polymerase family, member 4 (Parp4), (10ug)

MC225094 10 µg Ask for price

PARP4 ORF Vector (Human) (pORF)

ORF027423 1.0 ug DNA
EUR 486

Parp4 ORF Vector (Mouse) (pORF)

ORF053400 1.0 ug DNA
EUR 1886.4

PARP4 (Myc-DDK-tagged)-Human poly (ADP-ribose) polymerase family, member 4 (PARP4)

RC220444 10 µg Ask for price

Human PARP4 knockout cell line

ABC-KH11134 1 vial Ask for price
Description: Human PARP4 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human PARP4 knockdown cell line

ABC-KD11134 1 vial Ask for price
Description: Human PARP4 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human PARP4 Protein Lysate 20ug

IHUPARP4PLLY20UG each
EUR 361
Description: Human PARP4 Protein Lysate 20ug

PARP4 ELISA Kit (Human) (OKCD08347)

OKCD08347 96 Wells
EUR 1170
Description: Description of target: This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.061ng/mL

PARP4 ELISA Kit (Human) (OKDD00456)

OKDD00456 96 Wells
EUR 1170
Description: Description of target: This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.;Species reactivity: Human;Application: ;Assay info: Quantitative Sandwich ELISA;Sensitivity: < 0.061 ng/mL

PARP4, His-GST-Tag Recombinant

11394 50 µg
EUR 280
Description: Recombinant human PARP4 (poly(ADP-ribose) polymerase family member 4), encompassing amino acids 2-700. This construct contains an N-terminal His-tag (6xHis) followed by a GST-tag and a Thrombin Cleavage sight to facilitate removal of the GST-tag. This recombinant protein was affinity purified.  

OCOA12113-20UG - PARP4 Protein Lysate

OCOA12113-20UG 20ug
EUR 269

OPCD05991-10UG - PARP4 Recombinant Protein

OPCD05991-10UG 10ug
EUR 129

OPCD05991-50UG - PARP4 Recombinant Protein

OPCD05991-50UG 50ug
EUR 309

OPCD05991-200UG - PARP4 Recombinant Protein

OPCD05991-200UG 200ug
EUR 619

PARP4-AS1 ORF Vector (Human) (pORF)

ORF027424 1.0 ug DNA Ask for price

OKCD08347-96W - PARP4 ELISA Kit (Human)

OKCD08347-96W 96Wells
EUR 800

PARP4 sgRNA CRISPR Lentivector set (Human)

K1595801 3 x 1.0 ug
EUR 406.8

Parp4 sgRNA CRISPR Lentivector set (Mouse)

K4858201 3 x 1.0 ug
EUR 406.8

PARP4 3'UTR GFP Stable Cell Line

TU067410 1.0 ml
EUR 1672.8

Parp4 3'UTR GFP Stable Cell Line

TU165923 1.0 ml Ask for price

PARP4 Protein Vector (Human) (pPM-C-HA)

PV109692 500 ng Ask for price

PARP4 Protein Vector (Mouse) (pPM-C-HA)

PV213600 500 ng
EUR 3902.4

PARP4 Protein Vector (Human) (pPB-C-His)

PV109690 500 ng Ask for price

PARP4 Protein Vector (Human) (pPB-N-His)

PV109691 500 ng Ask for price

PARP4 Protein Vector (Human) (pPM-C-His)

PV109693 500 ng Ask for price

PARP4 Protein Vector (Mouse) (pPB-C-His)

PV213598 500 ng
EUR 3902.4

PARP4 Protein Vector (Mouse) (pPB-N-His)

PV213599 500 ng
EUR 3902.4

PARP4 Protein Vector (Mouse) (pPM-C-His)

PV213601 500 ng
EUR 3902.4

PARP4 3'UTR Luciferase Stable Cell Line

TU017410 1.0 ml
EUR 1672.8

Parp4 3'UTR Luciferase Stable Cell Line

TU115923 1.0 ml Ask for price

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx119585
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  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx128291
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx147654-100ug 100 ug
EUR 526.8

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx006130
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx174132
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  • 1 mg
  • 200 ug

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx322903
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  • 100 ug
  • 50 ug

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

20-abx339348
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  • 100 ul
  • 50 ul

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx006130-100l 100 µl
EUR 175

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx128291-100l 100 µl
EUR 275

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx128291-1ml 1 ml
EUR 750

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx128291-200l 200 µl
EUR 337.5

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx174132-100l 100 µl
EUR 787.5

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx174132-1ml 1 ml Ask for price

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx174132-200l 200 µl Ask for price

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx119585-100l 100 µl
EUR 312.5

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx119585-20l 20 µl
EUR 43.75

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx119585-50l 50 µl
EUR 237.5

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx339348-100l 100 µl
EUR 350

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx339348-50l 50 µl
EUR 250

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx322903-100g 100 µg
EUR 250

Poly ADP Ribose Polymerase 4 (PARP4) Antibody

abx322903-50g 50 µg
EUR 187.5

Parp4 (Myc-DDK-tagged) - Mouse poly (ADP-ribose) polymerase family, member 4 (Parp4). Note: ORF is codon optimized

MR215472 10 µg Ask for price

Parp4 (GFP-tagged) - Mouse poly (ADP-ribose) polymerase family member 4 (Parp4), (10ug). Note: ORF is codon optimized

MG215472 10 µg Ask for price

Human PARP4 Over-expressing Stable Cell Line

ABC-X2250 1 vial Ask for price
Description: Gentaur can provide custom lentiviral constructs expressing any genes of interest as long as it is less than about 3 kb. Lentiviral technology enables us to efficiently generate stable expression lines which are then selected for moderate or high expressers, depending on the experimental requirements. If you are interested in specific lentiviral DNA constructs or have further questions, please contact us to discuss the details. PARP4 poly (ADP-ribose) polymerase family, member 4 [ Homo sapiens ] http://www.ncbi.nlm.nih.gov/gene/143

PARP4 sgRNA CRISPR Lentivector (Human) (Target 1)

K1595802 1.0 ug DNA
EUR 184.8

PARP4 sgRNA CRISPR Lentivector (Human) (Target 2)

K1595803 1.0 ug DNA
EUR 184.8

PARP4 sgRNA CRISPR Lentivector (Human) (Target 3)

K1595804 1.0 ug DNA
EUR 184.8

Parp4 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4858202 1.0 ug DNA
EUR 184.8

Parp4 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4858203 1.0 ug DNA
EUR 184.8

Parp4 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4858204 1.0 ug DNA
EUR 184.8

Recombinant Poly ADP Ribose Polymerase 4 (PARP4)

RPU51583-100ug 100ug
EUR 492.8

Recombinant Poly ADP Ribose Polymerase 4 (PARP4)

RPU51583-1mg 1mg
EUR 2184

Recombinant Poly ADP Ribose Polymerase 4 (PARP4)

RPU51583-50ug 50ug
EUR 396

Recombinant Poly ADP Ribose Polymerase 4 (PARP4)

RPC984Hu01 10ug
EUR 160

Recombinant Poly ADP Ribose Polymerase 4 (PARP4)

4-RPC984Hu01
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  • Ask for price
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Poly ADP Ribose Polymerase 4 expressed in: E.coli

Lenti ORF particles, PARP4 (Myc-DDK tagged) - Human poly (ADP-ribose) polymerase family, member 4 (PARP4), 200ul, >10^7 TU/mL

RC220444L1V 200 µl Ask for price

Lenti ORF particles, PARP4 (Myc-DDK tagged) - Human poly (ADP-ribose) polymerase family, member 4 (PARP4), 200ul, >10^7 TU/mL

RC220444L3V 200 µl Ask for price

Human Poly ADP Ribose Polymerase 4 (PARP4) Protein

20-abx166526
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Poly ADP Ribose Polymerase 4 (PARP4) Protein

abx166526-100g 100 µg
EUR 537.5

Human Poly ADP Ribose Polymerase 4 (PARP4) Protein

abx166526-10g 10 µg
EUR 212.5

Human Poly ADP Ribose Polymerase 4 (PARP4) Protein

abx166526-50g 50 µg
EUR 375

PARP4 mouse monoclonal antibody, clone P193-6, Liquid

AM32037SU-N 1 ml Ask for price

PARP4 mouse monoclonal antibody, clone P193-4, Liquid

AM32038SU-N 1 ml Ask for price

PARP4 mouse monoclonal antibody, clone P193-10, Liquid

AM32039SU-N 1 ml Ask for price

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody

CAU23692-100ul 100ul
EUR 235.2

Poly ADP Ribose Polymerase 4 (PARP4) Polyclonal Antibody

CAU23692-200ul 200ul
EUR 294

Pig Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx360853-96tests 96 tests
EUR 990

ELISA Kit for Poly ADP Ribose Polymerase 4 (PARP4)

SEC984Hu 96Т
EUR 700

Human Poly ADP Ribose Polymerase 4 (PARP4) CLIA Kit

abx197521-96tests 96 tests
EUR 990

Human Poly ADP Ribose Polymerase 4 (PARP4) CLIA Kit

20-abx494031
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Poly ADP Ribose Polymerase 4 (PARP4) CLIA Kit

abx197521-100l 100 µl Ask for price

Human Poly ADP Ribose Polymerase 4 (PARP4) CLIA Kit

abx197521-50l 50 µl
EUR 618.75

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

20-abx152651
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

abx252901-96tests 96 tests
EUR 848.4

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

DLR-PARP4-Hu 96T
EUR 463
Description: tissue homogenates or other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

DLR-PARP4-Hu-48T 48T
EUR 620.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in samples from tissue homogenates or other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

DLR-PARP4-Hu-96T 96T
EUR 807.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Poly ADP Ribose Polymerase 4 (PARP4) in samples from tissue homogenates or other biological fluids.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

DL-PARP4-Hu 96T
EUR 441
Description: tissue homogenates or other biological fluids.

Human PARP4(Poly ADP Ribose Polymerase 4) ELISA Kit

EH3510 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

EKN47846-48T 48T
EUR 378.7

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

EKN47846-5x96T 5x96T
EUR 2569.75

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

EKN47846-96T 96T
EUR 541

Human Poly [ADP- ribose] polymerase 4, PARP4 ELISA KIT

ELI-12310h 96 Tests
EUR 988.8

Human PARP4(Poly ADP Ribose Polymerase 4) ELISA Kit

ELK3564-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PARP4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PARP4. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human PARP4, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PARP4 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human PARP4(Poly ADP Ribose Polymerase 4) ELISA Kit

ELK3564-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PARP4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PARP4. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human PARP4, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PARP4 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

EK15970 96Т
EUR 768

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

EKU06735-48T 48T
EUR 555.66

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

EKU06735-5x96T 5x96T
EUR 3770.55

Human Poly ADP Ribose Polymerase 4 (PARP4) ELISA Kit

EKU06735-96T 96T
EUR 793.8

Human PARP4(Poly ADP Ribose Polymerase 4) ELISA Kit

RE2445H-48wells 48 wells
EUR 116.55

Identifying hereditary cases of pancreatic cancer will help to offer more targeted treatments for patients and also to prevent cancer in family members who may be carriers of the mutation.